I believe you can! I am not really clear on why "20 are within 2 of models in base contact with Aegis" is relevant: if a model isn't obscured by the Aegis Line, it isn't benefiting from its cover save. In any case, the fact that Large Blasts do not roll To Hit does not affect how they allocate wounds "as for a normal shooting attack". So, you declare Focus Fire before rolling To Hit, roll your Disintegrators, shoot your missiles, count up your wounds, then your opponent starts allocating to the closest models without cover saves.