Actually, blast weapons can hit flying monstrous creatures as long as the firer has skyfire ("Shots resolved at such a target can only be resolved as Snap Shots unless the model or weapon has the Skyfire special rule" - p69), so if you don't mind being a bit of a tool a flier armed with splinter cannon and necrotoxin missiles should do pretty nasty things.
Even without the missile shenanigans, you've got two lances and 6 poisoned shots, which should make a reasonable dent regardless.