Sure. It's sort of like how in 6th edition, you could cause other models initiatives to get skipped if you could arrange a situation where on a single initiative that wasn't skipped, no allied and enemy models could reach base to base contact by piling in, thereby ending the combat.
You can still do something similar, but it's a much more specific scenario: With something like reavers that have a pretty heavy initial attack(HoW), you can charge a gunline from it's side. If you kill enough models on your HoW round to create more than a 6" gap between your models and the enemy, then the combat ends and you calculate assault results without the opponent getting to hit back. If they don't fall back, then you'd perform the end of combat pile-in.