I haven't played many games vs mech guard, but the games that I have played I need to either overpower one of his flanks, OR get close, quick.
Lately I've been looking at deepstriking vehicles (Venoms filled with Trueborn Blasters and Haywire Wyches) and have been thinking about this tactic vs Guard. But the problem with Guard is at range they hurt, and close up they spam Melta pretty well too.
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"I'm alive from this pain!"