I've done some fairly extensive stuff with Reaper.
There are two general catches;
First, generally speaking the Reaper minis are 28mm while GW minis are 'heroic' 28mm. What this means is that most GW minis will have larger heads and hands. One almost might say GW is also pushing the size thing a bit, and some argue that they are as large as 30mm sometimes. So, on average, the Reaper minis will be more fine and delicate seeming than a comparable GW mini.
Second, you are also getting to deal with the fact that Reaper has a lot of differing sculptors and lines under one roof, so even within their own lines there can be a little bit of adjustment one way or the other.
Overall though, I do think the two lines can mesh very well together.
Also, looks like I have a few unpainted minis on my desk right now that may help you to consider how they will work;