It depends on the size of the game, but anything that is 1850-2000 points would mean you should have more than 1 Talos.
You can have 3 Talos with Talos Gauntet, Macro Scalpel, and Haywire blasters comes to 330 points. If you give them Prophets of the Flesh, you have 330 points of a unit of 21 wounds with FnP, 4++ invulnerable save that can dish out mortal wounds in the firing phase and can pretty much deal with anything in Close Combat. Yes they do benefit from Urien, Cronus and Archons buffing them, but get those three stuck into a Knight and they will destroy it.